Tutors : dr hab. Michał Bielejewski, prof. IFM PANdr hab. Joanna Kowalczuk , prof. IFM PAN Institute of Molecular Physics, Polish Academy of Sciences, Poznań, Poland
The word diffusion derives from the Latin word diffundere, which means "to spread out". In the most general case, diffusion is a phenomenon that refers to the net movement of an object driven by a gradient of some magnitude factor. The process has a stochastic nature, and its concept plays an important role in many areas of physics, chemistry, biology, sociology, economics, and finance, constituting a broad field for research. In natural sciences, diffusion is not limited to a given state of matter but can occur in solids, liquids, and gases. It conditions the life processes by determining the transport through membranes, cells eventually, the whole body. In chemical processes, it is often the central rule driving many reactions. In physics, it defines many transport processes for atoms, ions, or molecules. A distinguishing feature of diffusion is that it depends on particle random walk and results in mixing or mass transport without requiring directed bulk motion. The first description of the diffusion phenomena was given by Adolf Fick in 1855. Fick's laws can be used to solve for the diffusion coefficient, D. A diffusion process that obeys Fick's laws is called normal or Fickian diffusion. On the other hand, it is called anomalous diffusion or non-Fickian diffusion if the process does not follow these laws. This tutorial aims to give an overview of the wide range of applications of diffusion NMR and principles of NMR diffusometry methods that allow insight, for example, for accurate molecular size determination, in nanomedicine drug delivery, or separation of complex mixtures.
Tutor: dr Jacek Jenczyk NanoBioMedical Centre, Adam Mickiewicz University, Poznań, Poland
The aim of the workshop will be to introduce and explain the basics of chemical shift anisotropy and dipolar interations. I will try to visualize the tensor formalism present in the description of both and thus, in an intuitive way, show a direct relationship between the molecular orientation relative to the laboratory reference system and the evolution of the NMR spectrum. Furthermore, we will discuss the physical significance of the shielding tensor geometry and confront it with the distribution of electronic charge density around the nucleus. We will also try to understand the origin of D tensor geometry. Finally, I will try to explain what actually happens to tensors under magic angle spinning conditions and how MAS influences and modulates effective shielding and dipolar coupling.
D tensor under MAS conditions
carbon shielding tensor in ethylene molecule
Tutors:
Tutor: Dr Rafał Konefał NanoBioMedical CentreAdam Mickiewicz University, Poznań, Poland
Polymers are substances composed of polymer molecules (macromolecules) formed through the repetition of smaller subunits. Due to their diverse properties, both artificial and natural polymers are integral to everyday life. They find applications across a vast array of fields, including electronics, packaging, textiles, energy, and healthcare (e.g., drug delivery). This tutorial focuses on the practical implementation of Nuclear Magnetic Resonance (NMR) spectroscopy as a crucial tool in polymer chemistry. Emphasizing its specialized applications, the session is divided into areas such as structural determination, monomer sequence analysis in copolymers, end-group analysis, and polymer chain dynamics and interactions. Rather than concentrating on theoretical aspects, the tutorial provides actionable insights for researchers. Key topics include:1. Sample Preparation: highlighting experimental challenges such as preparation of sample solutions, selecting appropriate solvents, and determining experimental parameters.2. Structural Analysis: determining polymers structure as well as structural details like tacticity, copolymer composition, molecular weight and reaction kinetics.3. Polymer Dynamics Analysis: Utilizing NMR relaxation experiments, such as T1, T2, DOSY and nuclear Overhauser enhancement (NOE), to investigate polymer chain dynamics and interactions in solution. It is our wish, that the basics in NMR measurements presented in this workshop will be helpful and useful for NMR users as well as newcomers into the field of polymer research.
Tutor: Dr Anna Zawadzka-Kazimierczuk Biological and Chemical Research Centre,University of Warsaw, Poland
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